EL's+Logbook+Week+of+Nov+5

1. Cancer** - Most cancers inherit a normal gene. - Genome stability (DNA) - maintian the molecular integrity of human genome. There is no change or mutation in the cell. - Genome stability controls the cause of cancer which is derived from the mutation of cell. - Control ON/OFF - Other ON/OFF controls
 * 11/05/07**
 * ===Information=== ||
 * **Genetic Update Conference 07-08 by Sam Rhine
 * **Genetic Update Conference 07-08 by Sam Rhine
 * Point mutation, Epigenetics-DNA methylation, Histone Methylation/Acetlyation, Non-coding DNA

1. Point mutation - Genome : The sum total of all the genetic information for a particular biological organism - 23, 688 proteins producing gene - Nucleotides - A, T, G, C in DNA - DNA is double helix : When one nucleotide attaches to another nucleotide, it is always opposite direction, or anti-parallel structure. - RNA is single helix. - Nucleotides - A, U, G, C in RNA - Abnormal protein causes CANCER! -- which means abrupt transcription or translation causes to create abnormal protein. - Coding DNA
 * Only 1.5% of whole DNA controls to produce the proteins.

- Non-Coding DNA
 * Does not code for protein, does code for RNA only

- MicroRNA = miRAN = miRs - only change in 1 nucletide in 285 billion can be fatal.

2. Epigenetics - Imprinting - It basically means inactivating a gene. - Histone methylation, hestone acetylation

3. Non-Coding DNA - RNAi : called gene silencing = block translation - C.elegans ( Caenorhabditis elegans )
 * C. elegans is 1mm size worm. It produeces enzymes that "dice" the inducer.

- In humans, 450 non-coding miRNA producing genes were discovered - Non coding genes are mostly located in intergenic regions(exon), but some are in intragenic introns. - Snc RNAs
 * miRNA - attach/detach to 3'
 * siRNA(short interfering) - attach and destroy gene permanently
 * smRNA (small modulatory)
 * rasiRNA (respect associated siRNAs) - transcendental epigenic CH3 ||
 * ===What I did & Opinion=== ||
 * 1. Went to Genetics Conference held at Rliey High School
 * It was such an amazing lecture. Even though it was long lecture which took about 5 hours straight, It was really interesting so I did not even
 * It was such an amazing lecture. Even though it was long lecture which took about 5 hours straight, It was really interesting so I did not even

fall asleep at all. The content discussed in the lecture will greatly help me in that it widely covers from the basic structure of protein to the mutation of protein cell. To prevent the cancer, there is various ways than I really expect. I discovered new method to prevent the mutation of protein such as using non-coding DNA. (non-coding DNA process is actually pretty recent discovered method, too) It will help me to analysis the structure of protein for the lab at Notre Dame. ||


 * 11/06/07**
 * ===Information=== ||
 * [|www12.i2u2.org:9080/elab/cosmic]
 * [|www12.i2u2.org:9080/elab/cosmic]

[|www12.i2u2.org:9080/elab/cms]

those two links are broken

[|www12.i2u2.org:8080/elab/cms.project.jsp] As you connect to this site, click student home and login as a guest. 1. Library tap : It provides basic information about CMS for the beginners. 2. Data tap : It helps the researchers to analysis the graph. 3. Poster tap : It displays various posters on CMS research from different groups. The viewers also can review it. 4. Site index tap : I can see the sitemap. ||
 * ===What I did & Opinion=== ||
 * 1. Explore CMS e-lab site ||
 * 1. Explore CMS e-lab site ||